Scientist Model, Systems
About Relation
Relation is a sector defining TechBio company developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life’s most devastating diseases. We leverage single-cell multi-omics from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure.
We are scaling rapidly and building a team of exceptional individuals to push the boundaries of drug discovery. You will work in highly interdisciplinary teams where biology, computation, and engineering come together to solve complex problems that have not been solved before. Our state-of-the-art wet and dry labs in the heart of London are designed to accelerate this integration and translate insight into impact.
We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the basis of gender, sexual orientation, marital or civil partnership status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age.
By joining Relation, you will help define how medicines are discovered and deliver meaningful impact for patients.
The opportunity
At Relation, we are building proprietary large-scale datasets to advance the prediction of disease-associated genes using cutting-edge functional genomics and machine learning approaches. We are offering an exciting opportunity for a Scientist to help expand our capabilities to run large scale perturbation studies on mono- and co-culture systems of fibrotic disease.
In this role, you will be at the forefront of scientific discovery and make a meaningful impact in the field of biology, working at the intersection of science and technology within a rapidly growing TechBio company. The successful candidate will contribute significantly to capture the cellular response using a multimodal readout strategy that includes transcriptomics, proteomics and molecular signatures of functional phenotype. You will partner closely with colleagues across Discovery, have the opportunity to develop your skills to work independently and advance your knowledge-base on assay development and optimisation.
Day to day, you will have the following key responsibilities:
Maintain human primary cell lines, taking responsibility for sample tracking and quality control (QC).
Perform experimental work developing cellular and biochemical assays
Benchmark and select candidate cell line, stimuli, timepoints, and assay dynamic range in monoculture and co-culture models
Execute perturbation screens on cell models
Contribute to the development and implementation of new technologies, workflows, and operational infrastructure.
Support the translation of assays into robust, high-throughput, automated workflows.
Carrying out data analysis and relevant quality assurance protocols
Monitor day-to-day lab activities, maintain tissue culture reagent stock levels, ensure equipment is properly maintained, and adhere strictly to good lab practice standards.
Communicate outcomes of your work to team members and external parties in written or verbal reports.
Stay up to date of relevant scientific literature and incorporate new findings into research project planning and experiment design
Proactive identification of potential project issues and communication of proposed solutions to the team
Communicate closely with cross-functional colleagues across biology, machine learning and automation disciplines and assist with solving complex scientific challenges and accelerate programme delivery
Professionally, you will have
PhD with 1-2 years experience and demonstrable experience in assay development and/or target validation or Master's degree in Biology with >5 years of additional experience in a relevant Biological Science.
Strong background in working with primary and immortalised cell lines, preferably within large batch cultures and using bioreactors
Experience with running functional disease relevant endpoints with necessary reproducibility and sensitivity.
Knowledge of CRISPR/Cas9 gene editing for modulating gene expression in 2D and 3D cell systems.
Prior involvement in pathway-modifying perturbation screens
Hands-on experience with High content imaging.
Extensive knowledge with data handling, curve-fitting and statistical analysis
Experience in industry-standard recording keeping
Excellent communication, influencing and interpersonal skills, with the ability to thrive in a collaborative, cross-functional, matrixed environment
High motivation, scientific rigor and be able to comfortably operate in a fast-paced, evolving biotech setting
Desirable knowledge or experience
Target modulation in fibrosis across various tissues is highly desirable
Working with ‘omics experiments and data sets
Experience with automated laboratory systems
Prior experience working within biotech, pharmaceutical or CRO environments
Personally, you
Are comfortable working in a matrixed environment, balancing multiple stakeholders and contributing effectively across teams.
Take ownership of your work, proactively seek opportunities to contribute, and enable others to do their best work.
Communicate openly and directly, give and receive feedback constructively, and handle challenging conversations with respect.
Actively seek out diverse perspectives, build strong working relationships, and contribute to shared goals across teams.
Embrace challenges with openness and resilience, set high standards for yourself, and strive to deliver meaningful outcomes.
Working Style & Culture at Relation
At Relation, we operate in a matrixed, interdisciplinary environment, where impact is driven through collaboration across scientific, technical, and operational domains. We collaborate, and you will partner with colleagues across multiple teams and projects, contributing your expertise while aligning to shared company priorities. We work together and win together! The patient is waiting!
Recruitment Agencies
Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs.
Relation is a committed equal opportunities employer.
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